regulondb信息库

RegulonDB是一个关于大肠杆菌K-12转录调控的模型以及其调控网络的资料库。 RegulonDB包含了基因在转录单位、操纵子以及简单和复杂的调节子中的组织知识。它整合了最佳表征的生物体大肠杆菌K-12的分散的科学知识,并且它的电子格式使试验人员可以将其后果与以前的知识进行比较,并支持的背后生物信息学工具和模型构建。 RegulonDB包含了基因在转录单位、操纵子以及简单和复杂的调节子中的组织知识。它整合了最佳表征的生物体大肠杆菌K-12的分散的科学知识,并且它的电子格式使试验人员可以将其后果与以前的知识进行比较,并支持的背后生物信息学工具和模型构建。 举报管

RegulonDB, first published 20 years ago, is a comprehensive electronic resource about regulation of transcription initiation of Escherichia coli K-12 with decades of knowledge from classic molecular biology experiments, and recently also from high-throughput genomic methodologies. We curated the literature to keep RegulonDB up to date, and initiated curation of ChIP and gSELEX experiments. We estimate that current knowledge describes between 10% and 30% of the expected total number of transcription factor- gene regulatory interactions in E. coli. RegulonDB provides datasets for in

RegulonDB version 2.0, a database on transcriptional regulation and operon organization in Escherichia coli, is now available on the web at the following URL: mx/Computational_Biology/regulondb/. In this paper we describe the main computational changes to the database, which include migrating.

机译:RegulonDB()是细菌基因调控方面最有用和最关键的资源之一,由于此它在组织大量资料的资料库中整合了最佳表征的生物体大肠杆菌K-12的分散的科学知识。它的电子格式使试验人员可以将其后果与以前的知识进行比较,并支持的背后生物信息学工具和模型构建。在这里,我们总结了自从上一本核酸试验出版物于2013年描述RegulonDB以来,RegulonDB的进展。除了保持最新的管理方法外,我们还报告了与影响192个基因的小RNA的232种相互作用以及完整的库。 189个基本的遗传感觉反应单元(GENSOR单元),整合了它们控制的信号,调节相互作用和代谢途径。这些加大代表了对受控过

AbstractRegulonDB is a database that contains the most comprehensive corpus of knowledge of the regulation of transcription initiation of Escherichia coli K-12, including data from both classical molecular biology and high-throughput methodologies. Here, we describe biological advances since our last NAR paper of 2019. We explain the changes to satisfy FAIR requirements. We also present a full reconstruction of the RegulonDB computational infrastructure, which has significantly improved data storage, retrieval and accessibility and thus supports a more intuitive and user-friendly experie

机译:RegulonDB是国际上主要的原始文献管理的主要资料库,具有有关大肠杆菌K-12转录调控网络的元素和相互作用的实验知识。这包括有关操纵子组织及其分解成转录单位(TUs),启动子及其σ类型,特定转录调节因子(TRs)的结合位点,它们组织成 调节短语 ,TRs的有效和无效构象的机制信息作为终止子和核糖体结合位点。该资料库补充有清楚标记的TU的计算预测,TR的启动子和结合位点。当前版本已扩展到包括旨在收集不同生长条件以及相关的诱导和/或抑制基因的特定机制以外的信息。 RegulonDB现在与Swiss-Prot,微阵列资料库以及一套用于检视和可视化微阵列实验的程序链接

RegulonDB|生物信息学资料集|资料库资料集 收藏Mendeley Data2024-02-04 更新2024-06-30 收录 生物信息学 资料库 下载链接: https://fairshari

RegulonDB ( is the primary reference database offering curated knowledge of the transcriptional regulatory network of Escherichia coli K12, currently the best-known electronically encoded database of the genetic regulatory network of any free-living organism. This paper summarizes the improvements, new biology and new features available in version 6.0. Curation of original literature is, from now on, up to date for every new release. All the objects are supported by their corresponding evidences, now classified as strong or weak. Transcription factors are classified by origin of their effectors a

RegulonDB is a DataBase that integrates biological knowledge of the mechanisms that regulate the transcription initiation in Escherichia coli , as well as knowledge on the organization of the genes and regulatory signals into operons in the chromosome. The operon is the basic structure used in RegulonDB to describe the elements and properties of transcriptional regulation. The current version contains information around some 500 regulation mechanisms, essentially for sigma 70 promoters. 更多 作者单位: Centro de Investigacion sobre Fijacion de Nitrogeno, UNAM A.P. 565-A Cuernavaca

RegulonDB is a model of the regulation of transcription initiation and the regulatory network in Escherichia coli K-12. It includes kn